SOLUTION

Parameters

Mammalia cell culture

Escherichia coli or Pichia yeast

Remark

Vessel working H/ID

2:1 (About)

3:1 (About)

System material
(product contact)

316L

316L

Vessel inner side finish

SF4

SF4, SF3, SF1

ASME BPE

Agitator and impeller

Bottom Magnetic Drive
Two layer Elephant ear
impeller, or Pitched blades

Top mechanical or bottom
magnetic Drive
Rushton, Hollow blade

Impellor type is available
according to client
process design

Washing

Clean In Place

Clean In Place

Sterilization

Empty SIP

Empty SIP, fully SIP

Temperature Control

Two plate exchanger TCU, high temperature accuracy

Customized design available

Culture monitor system

Foam level control

Foam level sensor interlocks with de-foaming agent pump in line

Customized design available

PH control

PH sensor interlock with alikali/Base addition pump in line

PH control

Dissolved Oxygen

DO Optical Sensor, interlocks (sequential cascade )with,
agitation speed, gassing rate, oxygen flow rate,head pressure.

Strain concentration

Live Cell concentration sensor (option)
Total cell concentration sensor (option)

Optical Density
Sensor (option)

Automation configuration

SIMENS PCS7,Delt-V, HMI+PLC